The Institute of Bioorganic Chemistry offers consumers medicinal preparations with antitumor and antiviral activity and initial nucleosides for their creation on the basis of a manufacturing agreement and is looking for partners to conclude a distribution services agreement.

Three new genetically engineered strains producing thermostable nucleoside phosphorylases have been constructed. For the first time, more than a dozen of inaccessible modified nucleosides have been synthesized using these enzymes.

As a result of a targeted search for new biologically important nucleosides, the molecular mechanism of activation of a key biocatalyst for the synthesis of nucleic acid components (purine nucleoside phosphorylase) was established, which provided the identification of a wide range of these compounds with potential activity against cancerous tumors and pathogenic viruses.

The work was carried out jointly with scientists from the Russian Federation, Germany, and the USA and published in Chemistry-A European Journal, 2015, 21, 13401-13419.

Reducing the cost of the synthesis of biologically active nucleosides due to the use of chemical-enzymatic technologies that have no analogs in the world.

A multienzyme cascade strategy for the synthesis of a wide range of nucleosides for the creation of drugs with antitumor and antiviral activity has been developed and experimentally tested, ready for the purposeful creation on its basis of a new generation of biotechnologies for the formation of compounds of a nucleic nature of the desired design and biological activity.

RB Patent No. 19553 "Escherichia coli strain producing pyrimidine - cleoside phosphorylase Thermus thermophilus ".

The institute has an experimental base for studying the biological activity of the obtained compounds at the cellular level and in tests on animal models. For pilot production of the developed products (hemosorbents, preparations of recombinant enzymes, immunochemical reagents, oxyphitosterols, etc.), 5 experimental production sites have been created at the institute.

The results of fundamental and applied research on methods and means of protecting plants from diseases, insects, weeds, and other unfavorable environmental factors that are safe for humans and the biosphere as a whole were the basis for the development of methods for obtaining new plant growth stimulators, pheromone compositions (pheromones of the codling moth LP -U and mill moth), active ingredients of pesticides (analogs of the herbicide Grasp and insecticide Confidor), formulations of pesticides (herbicides, insecticides, fungicides, etc.).

The created intellectual property of the Institute today consists of patents maintained in force, laboratory technological and experimental industrial regulations, technical specifications, and trademarks. Licensing agreements are in force for the transfer of technologies for the production of immunodiagnostic products, hemosorbents, and pesticides to manufacturers.

Consumers interested in purchasing the medicinal preparations with antitumor and antiviral activity and initial nucleosides for their creation under a manufacturing agreement.

Distributors interested in purchasing the medicinal preparations with antitumor and antiviral activity and initial nucleosides for their creation under a distribution services agreement.