The Institute of Bioorganic Chemistry offers consumers a technology for the synthesis of 14β-(isoxazol-3-yl) methylsteroids under a commercial offer with technical support and is looking for partners to conclude a recearch cooperation agreement.

The cleavage of the heterocycle under different conditions was studied, criteria for the selectivity of reactions were established, and rearrangement products were determined by 2D NMR. Pathways for modifying bridging nitrosteroids in order to obtain compounds with cytostatic activity have been determined, and criteria have been identified that determine the biological activity of the products of transformation of bridging nitrosteroids.

The discovery of new reactions or new transformations in a certain series of compounds, the proof of the structure of new compounds, the establishment of a structure-function relationship, the determination of the specific biological activity of organic compounds, in particular modified steroids, are relevant today and are the basis of synthesis technology.

Innovative synthesis technology

Ladyko, А. Structure modification of 14-isoxazolylmethyl steroids / А. Ladyko, А. Baranovsky // Chemistry, structure and function of biomolecules, Minsk, 22-24 May, 2018. - P. 130.

Main activities:
- fundamental and applied research in the field of chemistry, structure and function of biopolymers and low molecular weight bioregulators, including proteins, nucleic acids and their components, phospholipids, steroids, prostaglandins, brassinosteroids, ecdysteroids;
- development and pilot production of immunochemical and molecular biological reagent kits for medical and veterinary diagnostics;
- development and production of pharmaceutical substances, hormonal preparations and biospecific hemosorbents;
- development of technologies for the production and use of growth stimulants and plant protection products;
- experimental and clinical pharmacology, pharmacy and drug technology, toxicology, human and animal biochemistry, biomedical and pharmaceutical chemistry;
- preclinical, bioequivalent and pharmaceutical trials.

The Institute of Bioorganic Chemistry successfully develops international relations in the main areas of its research. Currently, the Institute conducts joint research with scientific institutes of the CIS countries, Germany, USA, Canada, Sweden, Finland, Denmark, Holland, Vietnam and other countries.

Consumers interested in purchasing the technology for the synthesis of 14β-(isoxazol-3-yl) methylsteroids under a commercial agreement with technical assistance.

Partners interested in improving of the technology for the synthesis of 14β-(isoxazol-3-yl) methylsteroids under a research cooperation agreement.