The Institute of Physiology offers consumers services for conducting scientific research for the real sector of the economy using methods for studying electrical activity in sections of rat nervous tissue using a hardware and software complex under an outsourcing agreement and is looking for partners interested in a distribution services agreement.

The following tasks are solved in the course of the work:
- study of the effect of neuroactive substances on functional processes in nervous tissue in the interests of the pharmacological industry in the development of new drugs;
- modeling of pathological conditions in nervous tissue in vitro for the development of methods for their correction in the creation of new methods of therapy of socially significant diseases;
- improving the level of professional training of students of specialized universities. Carrying out specialized scientific research.

Methods of studying electrical activity are carried out in sections of rat nervous tissue in vitro using a specialized multichannel amplifier of biopotentials and a flow-through recording chamber with an infusion pump for the introduction of tested drugs.

Scope - scientific research, biomedical and pharmacological industries, educational process.

Information is posted in the "Album of Promising Developments of Organizations of the National Academy of Sciences of Belarus for the Real Sector of the Economy" (2023), pp. 369-370. (in Russian)

Possibility of setting up and reconfiguring the methodological support depending on the requirements of the experiment.
Conducting studies of the electrical activity of neurons and synaptic plasticity of neurons in rat brain slices under controlled external influences.

Safe for the environment.
Possibility of flexible setting up of experimental conditions depending on the customer's requirements.

1. Analysis of the electrical activity of neurons in rat hippocampal slices during extracellular recording in vitro / A. A. Denisov [et al.] // News of medical and biological sciences. - 2021. - Vol. 21, No. 3. - P. 26-27. (in Russian)
2. Hardware and software system for studying electrical activity and synaptic processes in nervous tissue in vitro / A. A. Denisov [et al.] // Physicochemical biology as the basis of modern medicine: materials of the Int. scientific conf., Minsk, May 21, 2021 - Minsk, 2021. - P. 95-97. (in Russian)
3. Denisov, A. A. Flexible microelectrode based on carbon fiber with polydimethylsiloxane insulation for recording extracellular electrical activity of neurons / A. A. Denisov // News of medical and biological sciences. – 2022. – V. 22, No. 4. – P. 77–81. (in Russian)
4. Denisov, A. A. Complex for studying the brain / A. A. Denisov // Navuka. – 2021. – No. 30. (in Russian)

The Institute is a leading scientific institution coordinating physiological research in the Republic of Belarus.

The institute successfully carries out fundamental and applied research aimed at developing methods for the prevention and correction of pathological conditions of hypoxic, ischemic and inflammatory genesis, and develops new devices and methods for their therapeutic and prophylactic use. The main scientific activity of the departments is currently focused on studying the mechanisms of the formation of pathological conditions of the body (primarily hypoxic and neurodestructive) and substantiating new technologies for prevention, treatment and rehabilitation. Particular attention is paid to the development of complex methods for the treatment of malignant tumors using metabolic blockade effectors and high-intensity pulsed magnetic fields and methods for controlling the proliferation of tumor cells based on changes in the functional state of neuroreceptors in vitro and in vivo, as well as the development of a method for immunotherapy of patients suffering from pancreatic cancer. , using autologous dendritic cells primed with tumor antigens and elucidating new mechanisms of tumor formation, substantiation of prevention methods. Studies of the molecular mechanisms of proliferation, differentiation and oncogenesis are being carried out; physiological and therapeutic effect of physical factors and the development of new technologies of physiotherapy and physiotherapy equipment and experimental analysis of positive and negative aspects of the use of nanoparticles and heterocyclic compounds in biomedical technologies. The neurophysiological bases of dysregulation of the functions of internal organs during ischemia of the nervous tissue of various origins are being studied. Works on the physiology of nutrition and sports are being carried out. Preclinical studies of drugs and nanomaterials are underway. Research is being carried out on the safety of biosubstances, biotherapeutic agents, pharmacological complexes and medical products on the basis of agreements with manufacturing enterprises and research institutions. The staff of the Institute conducts research on the mechanisms of interaction between neurons and glial cells in normal and pathological conditions. The functional role of biological preparations (platelet-rich plasma, suspension of mitochondria, mesenchymal stem cells, etc.) in the activation of reparative processes in strokes and brain injuries, ischemia of the lower extremities is being studied. Methods for stable remote monitoring of vital human functions (heart, blood vessels, respiration, temperature, motor activity, brain activity) are being developed. Particular attention is paid to the study of the functional role of the extracellular matrix and stem cells in the development of neoplasms. Cell technologies are being developed for the treatment of malignant diseases. The Institute also evaluates the therapeutic and therapeutic-prophylactic properties of natural mineral waters and the effectiveness of pre- and probiotics - food, food supplements.

Close scientific cooperation is carried out with scientists from Russia, China and Uzbekistan.

Consumers interested in purchasing services for conducting research and development work for the real sector of the economy using methods for studying electrical activity in rat nervous tissue sections using a hardware and software complex under an outsourcing agreement.

Partners interested in purchasing services for conducting research and development work for the real sector of the economy using methods for studying electrical activity in rat nervous tissue sections using a hardware and software complex under a distribution services agreement.