UW-Madison researchers have developed an improved covalent labeling system for use in protein footprinting. The innovation of the present disclosure advances a currently existing technology -- a covalent labeling system called EDC/GEE (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/glycine ethyl ester), which modifies solvent accessible aspartate and glutamate residues. To advance this technique for the application of proteome-wide footprinting, the inventors have replaced the GEE with GPA (glycyl propargyl amide), to now become an EDC/GPA technique. GPA produces a more stable, single modification on a protein.Â
UW-Madison researchers have developed a novel xylose fermenting S. cerevisiae yeast capable of converting xylose into ethanol. The researchers did an extensive analysis of xylose fermentation activity in a variety of yeast species and found that xylose reductase from Scheffersomyces xylosifermentans acted in a cofactor independent manner which means that this gene can produce ethanol from xylose under anaerobic conditions. Adding this gene into S. cerevisiae converted the yeast from one that produces xylitol under anaerobic conditions into one that produces ethanol under anaerobic conditions.
The invention presents a novel receiver architecture designed for ultra-high-speed communications, employing a carrier synchronization loop and a high-speed pipelined structure. This architecture uniquely demodulates high-order QAM signals directly into raw bit-streams, bypassing the need for ADCs in the signal path and addressing the critical bottleneck in conventional receiver designs.
Researchers at UC Irvine developed a synergistic method for bacterial eradication by combining bacterial pore-forming agents with histones. Histone additives stabilize the transient pores caused by antibiotics or antimicrobial peptides, preventing bacteria from repairing the membrane, which leads to death. This approach addresses the urgent need for new antimicrobial strategies due to the rise of antibiotic-resistant bacterial strains.
Researchers at UC Irvine have developed a novel MRI processing method by strategically combining Diffusion Tensor Imaging (DTI) alongside Statistical Parametric Mapping (SPM) as an effective diagnostic tool for Traumatic Brain Injury (TBI). Their research has shown a maximal Area Underneath the Receiver Operating Characteristic Curve (AUROC) of 1.000, indicating perfect diagnostic capability.
IRIS is a novel imaging technology designed to visualize the surface of optically transparent materials with exceptional clarity and detail. By adjusting structured illumination—its type, size, intensity, and periodicity—IRIS can discern minor surface variations, including deformities and contaminants. This technology has proven its worth in visualizing surfactant production by bacteria on a soft agar surface, showcasing its ability to monitor movement and changes at liquid-solid and liquid-liquid interfaces.
Researchers at UCI have developed a novel cement and its manufacturing process as a sustainable alternative to Portland cement, traditionally known for its high carbon footprint. Unlike conventional methods requiring temperatures above 1400 °C and resulting in significant CO2 emissions, this new approach manufactures cement at room temperature and enables concrete components with long-term CO2 sequestration capabilities and essential mechanical strength for structural uses.