Institute of Physical Organic Chemistry offers consumers synthetic RNA oligonucleotides, guide RNA for CRISPR genome editing technology, modified RNA oligonucleotides under a manufacturing agreement and is seeking partners interested in a distribution services agreement.

Developed to solve a national economic problem - ensuring the availability of reagents for molecular biological and genetic research on the domestic market.

The quality is not inferior to world analogues at a lower cost. The possibility of introducing modifications on individual requests in accordance with the customer's tasks.

Scope - For the development of gene therapy drugs, scientific research in the field of molecular biology and genetics.

The technologies are import-substituting and have no analogues on the domestic market. The emergence of affordable domestic RNA oligonucleotides will contribute to the development of domestic biomedicine. On the foreign market, demand is primarily due to individual orders for modified RNA oligonucleotides of a special structure containing complex modifications for targeted delivery of therapeutic RNA to target cells.

Information is posted in Album of promising developments of the NAS of Belarus organizations for the real sector of the economy (2023), p. 161-162. (in Russian)

In terms of purity, they are not inferior to imported analogues. Biological activity is confirmed by publications in rating international journals.

Possibility of introducing a wide range of modifications using reagents of our own production.

The developed technologies are environmentally safe.

RNA oligonucleotides are produced under conditions of automated solid-phase synthesis by highly qualified personnel on specialized equipment.

The Institute is a world leader in the development, production and use of ion-exchange fibrous materials and artificial substrates for plant cultivation. The Institute's work in the field of membranes and membrane technologies is widely known. Membrane materials for ultra- and microfiltration in the form of continuous webs and capillaries, cassette, roll and hollow fiber elements for use in energy, food, pharmaceutical, electronic and other industries have been developed and manufactured.

The Institute's scientists have discovered and studied the reactions of: heterocyclization of azomethines with carbonyl compounds, hydroamination of oxygen-containing compounds, initiated decarboxylation of mercury acylates, construction of an isothiazole cycle from 2-nitropentachlorobutadiene and sulfur. Convenient methods for synthesizing benzoquinolines, amines, pyridines, organomercury compounds, electrochemical methods for obtaining p-complexes of transition metals, methods for synthesizing various functional substituted organohalogen compounds, carboranes and peroxides have been developed.

The catalysts developed at the Institute have been implemented at the largest chemical plants. An antiblock composition preventing cellophane film from sticking together during its production has been implemented on an industry-wide scale. An industrial radiation-chemical technology for obtaining the blood plasma substitutes "Rondeks" and "Neorondex" has been developed.

The Institute's activities are aimed at developing scientific principles and technologies for creating new polymeric materials with special properties (selectively permeable, sorption, ion-exchange, catalytically active) for use in industry, ecology, agriculture, water treatment; development of methods for the synthesis and technologies for obtaining medicinal substances based on amino acids and their derivatives, biologically active substances and compositions for medicine and agriculture, functionally substituted organic and organoelement compounds.

The Institute carries out international scientific and technical cooperation within the framework of direct agreements with scientific institutions of Russia, Ukraine, Germany, Poland, Sweden, China, etc. Much attention is paid to the implementation of contracts for the conduct of research and development work and the manufacture of high-tech commercial products based on its own developments with organizations and firms in Saudi Arabia, Germany, Korea, Russia, and the USA.

Consumers interested in purchasing synthetic RNA oligonucleotides, guide RNA for CRISPR genome editing technology, modified RNA oligonucleotides under a manufacturing agreement.

Partners interested in purchasing synthetic RNA oligonucleotides, guide RNA for CRISPR genome editing technology, modified RNA oligonucleotides under a distribution services agreement.