B.I.Stepanov Institute of Physics of the National Academy of Sciences of Belarus offers consumers phototherapeutic apparatuses «LOTOS» for the treatment of infectious and inflammatory diseases of newborns and children in the first months of life using methods of antibacterial photodynamic therapy and photoregulatory therapy under a manufacturing agreement and is looking for partners interested in a distribution services agreement.

B.I.Stepanov Institute of Physics of the National Academy of Sciences of Belarus manufactures phototherapeutic apparatuses «LOTOS» designed for the treatment of infectious and inflammatory diseases of newborns and children of the first months of life using methods of antibacterial photodynamic therapy and photoregulatory therapy.

Due to its wide functionality, «LOTOS» apparatus can be used for the treatment of diseases of various etiologies, which can hardly be treated with medication, by affecting the lesions with a size of 50x50 mm (using laser module). Remote emitters can be used for hard-to-reach lesions (ears, etc.).

Distinctive features of the phototherapeutic apparatus «LOTOS» are:
* opportunity of application of methods of antibacterial photodynamic therapy with photosensitizers used in clinical practice and the method of photoregulatory therapy;
* opportunity of a significant increase of biological activity and therapeutic effect of radiation due to the combined treatment of the lesions with polarized radiation of purple and red spectrum regions during photoregulatory therapy;
* opportunity of discrete regulation of laser radiation parameters;
* lack of resistance in pathogenic microflora to the damaging effects of reactive oxygen species generated by a triplet-excited sensitizer, as well as the availability of drugs used as photosensitizers;
* high efficiency of sensitized destruction of pathogenic microflora due to the formation of complexes of the sensitizer drug with the protein structures of microbial cells, which are the primary targets of reactive oxygen species, as well as a high quantum yield of singlet oxygen generation by medications.

Specifications:

Electrical protection class	II, type V
Laser hazard class	II
Number of independent channels	3
Laser type	continuous-wave diode laser
Laser radiation wavelength, nm	405 and 650
Maximal power of laser radiation density, mW/cm2	10
Maximal laser radiation power, mW	50
Maximal power consumption, V·A	30
Operation mode	manual, timer
Power supply voltage, V/Hz	220/50

Area of application: medicine (neonatology).

B.I. Stepanov Institute of Physics offers partners:
* phototherapeutic apparatuses «LOTOS» for the treatment of infectious and inflammatory diseases of newborns and children in the first months of life using methods of antibacterial photodynamic therapy and photoregulatory therapy under a manufacturing agreement;
* phototherapeutic apparatuses «LOTOS» for the treatment of infectious and inflammatory diseases of newborns and children in the first months of life using methods of antibacterial photodynamic therapy and photoregulatory therapy under a distribution services agreement.

Catalogue of developments & services of «B.I. Stepanov Institute of Physics» 2022, p. 61.

Link on the B.I.Stepanov Institute of Physics site.

Phototherapeutic apparatus «LOTOS» has no analogues in the countries of the Commonwealth of Independent States.

The methods of photodynamic therapy make it possible to shorten the duration of treatment, increase the frequency of complete cure, and partially abandon the use of foreign expensive drugs, including those based on heavy metals.

Patents of the Russian Federation:
№ 2497518 "Photosensitizer for antimicrobial photodynamic therapy";
№ 2550132 "Method of photodynamic inactivation of bacteria Enterococcus faecalis (options)".

Patents of the Republic of Belarus:
№ 17107 "Method of photodynamic therapy of cervical ectopia";
№ 17108 "Method for the treatment of cervical ectopia";
№ 19243 "Method for the prevention or correction of side effects of chemotherapy of tuberculosis in adolescent children",
№ 20000 "Method for treating a purulent inflammatory focus";
№ 19243 "Method for the prevention or correction of side effects of chemotherapy of tuberculosis in adolescent children",
№ 20007 "Method for treating exudative pleurisy (options)".

The directions of scientific research and development of the B.I.Stepanov Institute of Physics are currently:
* Laser physics, development and creation of laser systems and technologies for medicine, ecology, industry, metrology and information protection;
* Physical and nonlinear optics, the disclosure and use of the patterns of propagation of high-power laser radiation in various media;
* Optical spectroscopy, development and application of methods and instruments for studying the properties and structure of various materials, including biotissues;
* Nanooptics and Nanomaterials;
* Quantum optics, investigation of quantum properties of electromagnetic radiation in computer science and cryptography;
* Investigation of the structure and properties of atomic-molecular structures and the creation of new optical materials, systems, instruments and technologies on this base;
* Plasma physics and plasma technologies: investigation of the plasma interaction with fields and matter; development and application of methods for plasma diagnostics, development of technological applications of gas-discharge and laser plasma
* Micro- and optoelectronics: LED technology, solar cells, microwave technology, microelectromechanical and sensor systems and devices;
* Physics of Fundamental Interactions and Nuclear Reactions - Investigating the Structure of the Microcosm and the Universe.

The B.I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus has scientific contacts with many countries. At present, more than 50 agreements on scientific and technical cooperation have been signed with organizations from 15 countries.

The Institute develops, manufactures and supplies laser and optical instruments for various purposes, as well as innovative components for laser technology, to many countries of the world (Russia, China, Germany, France, the United States, Saudi Arabia, India, etc.).

Consumers interested in purchasing phototherapeutic apparatuses «LOTOS» for the treatment of infectious and inflammatory diseases of newborns and children in the first months of life using methods of antibacterial photodynamic therapy and photoregulatory therapy under a manufacturing agreement.

Partners interested in purchasing phototherapeutic apparatuses «LOTOS» for the treatment of infectious and inflammatory diseases of newborns and children in the first months of life using methods of antibacterial photodynamic therapy and photoregulatory therapy under a distribution services agreement.