The Institute of Chemistry of New Materials offers to consumers a technology for the production of nanocatalysts using halloysite nanotubes for the stereoselective production of biologically active heterocyclic compounds (octahydro-2H-chromen-4-ols) from natural terpenoids (isopulegol) under a license agreement and/or a commercial agreement with technical assistance and is looking for partners to conclude a technical cooperation agreement.

New nanocatalysts based on halloysite nanotubes for stereoselective production of biologically active heterocyclic compounds (octahydro-2H-chromene-4-ols) from natural terpenoids (isopulegol).

High reactivity and multivariance of terpene conversions lead to the formation of complex reaction mixtures with low yields of target products. An increase in the yield can be achieved through the use of highly selective catalysts. It has been established that natural halloysite nanotubes are a promising basis for the creation of new catalytic systems for the synthesis of heterocyclic compounds. The use of nanocatalytic systems based on halloysite nanotubes opens up broad prospects for the stereoselective synthesis of physiologically active heterocyclic compounds based on monoterpenoids.

A method has been developed for directed chemical and thermal modification of natural halloysite nanotubes, which makes it possible to create on its surface catalytically active regions of Lewis and Bronsted nature with a certain concentration and acidic strength. A mechanism has been proposed for the specific catalytic action of nanotubes, which ensures the formation of an intermediate of a certain structure and the transfer of water molecules from the surface of nanotubes to this compound, leading to the formation of the 4R-stereoisomer.

It was found that the selectivity of the reaction of isopulegol terpenoid with aldehydes in octahydro-2H-chromene-4-olam reaches 94.2%, which is significantly higher than on other catalytic systems. The yield of the individual 4R ‑ isomer of thiophenyl-substituted chromenol with a high analgesic effect is 80%, which is significantly higher than with the imported catalyst K ‑ 10 (64%).

The Institute of Chemistry of New Materials is the leading institute in the Republic of Belarus and one of the leaders in fundamental and applied research in the field of creating thin-film and nanostructured organic materials, new composite materials with specified properties, methods for synthesizing new organic compounds as potential physiologically active substances.

Currently, the main objective of the Institute is to conduct scientific research in the field of high technologies for obtaining new chemical materials for various functional purposes, including:
- creating thin-film (including nanostructured) organic materials with specified properties;
- developing new composite materials with specified properties based on forest and petrochemical products and technologies for their production.

The scientific and scientific-technical activities of the Institute are also aimed at solving problems in the interests of enterprises: the Ministry of Industry, Belneftekhim Concern, Bellesbumprom Concern, State Military Industrial Committee, Ministry of Agriculture and Food, Ministry of Health and Belbiopharm Concern, RUE Cryptotech and the Minsk Printing Factory of the Goznak Department of the Ministry of Finance of the Republic of Belarus.

The Institute has high scientific and technical potential, has a modern research base, the latest experimental equipment, allowing to carry out complex scientific research in the areas of activity, is able to ensure high-quality performance of scientific research and development, practical development of results and conduct training of highly qualified scientific personnel.

Over the years of the Institute's existence, the results of scientific developments of the Institute of Chemistry of New Materials have been exported to Saudi Arabia, the Republic of Korea, China, India, Vietnam and other countries.

The Institute conducts research in broad international scientific cooperation with scientific centers of Russia, Azerbaijan, China, Vietnam, Saudi Arabia, the USA, Poland, Germany, regularly holds international conferences on the problems of obtaining science-intensive low-tonnage chemical products of various functional purposes.

Consumers interested in purshasing the technology for the production of nanocatalysts using halloysite nanotubes for the stereoselective preparation of biologically active heterocyclic compounds (octahydro-2H-chromen-4-ols) from natural terpenoids (isopulegol) under a license agreement and/or a commercial agreement with technical assistance.

Partners interested in developing the technology for the production of nanocatalysts using halloysite nanotubes for the stereoselective preparation of biologically active heterocyclic compounds (octahydro-2H-chromen-4-ols) from natural terpenoids (isopulegol) under a technical cooperation agreement.